The main purpose of this study is to investigate the relationship between political uncertainty and the level of cash holdings of companies listed on the Tehran Stock Exchange. The present study is in the group of descriptive-post-event research in terms of applied purpose and in terms of data collection method. The statistical population of the present study is all companies listed on the Tehran Stock Exchange in a period of 6 years between 1392 to 1397, which based on the sampling method of systematic removal of 150 companies and a total of 900 years-companies as a statistical sample. Was taken. The effect of sales change coefficient variable was measured as an indicator of the company's political uncertainty on their level of cash holdings. Also, the effect of firm size variables, market value to book ratio, cash flows, working capital, capital expenditures, financial leverage, industry cash flow fluctuations, profit sharing and research and development costs was controlled in a regression model to test the hypothesis. Multivariate regression models were used using Eviews8 software and panel (panel) data method - fixed effects. The results of this study show that there is a relationship between political uncertainty and the level of holding cash of the company.