The aim of this study is to investigate the effect of entrepreneurial orientation and board tenure on the financial performance of companies listed on the Tehran Stock Exchange. In this study, financial performance (return on total assets) was considered as the dependent variable, entrepreneurial orientation as the independent variable, and board tenure as the moderating variables. The research method is applied and the method of collecting archival data. The statistical sample includes 95 companies during the period 1393 to 1402 (the total number of observations is equal to 950 company-years). Hypothesis testing was performed using multivariate linear regression and using the Iviews software. The results of the study showed that the entrepreneurial orientation of the senior management team and board tenure have a significant relationship with the financial performance of companies, but board tenure does not moderate the relationship between the entrepreneurial orientation of the senior management team and the financial performance of companies.